Zonulin1 is a uniquely formulated to regulate tight junctions in the gastrointestinal tract and Blood . Zonulin1 reduces serum zonulin, intestinal hyperpermeability, inflammation in the gut and neuro-inflammation all of which are associated with many common Autoimmune diseases. The components in Zonulin1 ingredients, including saikosaponin, paeoniflorin, naringin and glycyrrhizic acid have a powerful sorbefacient effect to regulate tight junctions than a single drug. Ingredients Ingredients Bupleurum falcatum Paeonia lactiflora Citrus aurantium Glycyrrhizae uralensis Lactobacillus acidophilus Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate. Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts Actions & Indications Zonulin160 x 500 mg capsulesZonulin1 is a uniquely formulated to regulate tight junctions in the gastrointestinal tract and Blood . Zonulin1 reduces serum zonulin, intestinal hyperpermeability, inflammation in the gut and neuro-inflammation all of which are associated with many common Autoimmune diseases. The components in Zonulin1 ingredients, including saikosaponin, paeoniflorin, naringin and glycyrrhizic acid have a powerful sorbefacient effect to regulate tight junctions than a single drug.The combination of Radix Bupleuri and Radix Paeoniae Alba, which is used to relieve depression, has antidepressant effects. The antidepressant mechanism of combined Radix Bupleuri and Radix Paeoniae Alba treatment may be related to the oxidative stress response, neuroplasticity, the immune response, and neuroprotection.Primary IndicationsAutoimmune Diseases including:Inflammatory Bowel DiseasesCeliac DiseaseChronic Fatigue SyndromeMultiple SclerosisLeaky GutNeuroinflammationLong COVID Neurocognitive symptoms and depressionPrimary ActionsHelps repair gastrointestinal tight junctionsLowers serum ZonulinReduces intestinal hyperpermeabilityDown-regulates inflammatory cytokinesReduces neuro-inflammation-mediated neuro-degeneration through suppressing NF-?B-mediated inflammatory pathwaysAnti-depressantDosage:2 - 3 capsules twice daily. Measurement of stool sample will determine length of treatmentContraindicationsPregnancy