Affect D is an anxiolytic and sedative and may be used for medium to severe depression, bi-polar disorders, acute insomnia, OCD and PTSD. Affect D combines Western therapeutic compounds with traditional Chinese herbs as well as a specific molecular extract from a famous pain herb. Affect D is an all-natural product, which has similar therapeutic effects of well-known pharmaceuticals to treat severe psychological conditions. Ingredients Affect D is a superior combination of botanicals and isolates. Psychopharmacologic indications include Post Traumatic Stress Disorder (PTSD) Obsessive Compulsive Disorder (OCD) and depression. Ingredients Cyanocobalamin Levomefolate calcium Methionine Phenylalanine Pyridoxal-5-Phosphate Zinc succinate Bupleurum falcatum Curcuma longa Cyperus rotundus Dalbergiae odoriferae Hypericum perforatum Magnolia officinalis Ziziphus jujuba var spinosa Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate. Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts Actions & Indications Affect-DAffect D is an anxiolytic and sedative and may be used for medium to severe depression, bi-polar disorders, acute insomnia, OCD and PTSD. Affect D combines Western therapeutic compounds with traditional Chinese herbs as well as a specific molecular extract from a famous pain herb. Affect D is an all-natural product, which has similar therapeutic effects of well-known pharmaceuticals to treat severe psychological conditions.ActionsRelieves medium to severe depressionBalances moodAnxiolyticSedativeRegulates sleeping patterns and improves daytime alertnessTreats physical and mental fatigueAssists with optimum cognitive functioningStimulates neuronal regeneration in the brainIncreases 5-HTPIndicationsMedium to severe depressionBi-polar disordersAcute insomniaOCDPTSDSuggested Use:1 - 2 capsules dailyRecommended to start with lower dose for 1 - 2 weeksCaution:Caution is to be used when the patient has a history of liver disease and/or hepatitis as Corydalis may increase liver enzymes in some patientsBe very cautious when prescribing together with conventional medicines, pregnancy and breastfeedingWill have additive effect on psychotropic drugs and may cause drowsiness5-methyltetrahydrofolateLikely Safe:When used orally or parenterally and appropriately. 5-methyltetrahydrofolate is safe when used in doses lessthan 1000 mcg per day. In cases of megaloblastic anaemia resulting from folate deficiency or malabsorptiondisorders such as sprue, oral doses of 1-5 mg per day can also be used safely if vitamin B12 levels are routinely measured until hematologic recovery is documented.Warning: In very rare cases, Curcuma species may harm the liver. Stop use and see a doctor if you have yellowing skin/eyes or unusual: fatigue, nausea, appetite loss, abdominal pain, dark urine, or itching. If symptoms persist, talk to your health professional. Contains vitamin B6. St Johns Wort affects the way many prescription medicines work, including the oral contraceptive pill. Consult your doctor. Vitamin supplements should not replace a balanced diet. This product contains pyridoxal 5-phosphate as applicable, which may be dangerous when used in large amounts or for a long time. Stop taking this medication if you experience tingling, burning or numbness and see your healthcare practitioner as soon as possible. Phenylketonurics are warned that this product contains phenylalanine. Not permitted for use in children aged below 2 years. Contains Phenylalanine, do not use with MAO inhibitors for depression or if any of the following conditions are present:phenylketonuria(PKU)hepatitiscirrhosisliver damagemelanomamigraine headacheRadix Bupleuri (chai hu) should be considered contraindicated in the treatment of solid tumours, but not necessarily for haematological cancers. A research article by Shyu et al., (2004) indicated that chai hu promotes endothelial cells growth, migration and angiogenesis and therefore should be cautioned in its use. Note that this was for one fraction while other fractions may have differing effects.Possibly Unsafe:When used orally in large doses. Doses above1000 mcg per day should be avoided if possible to prevent precipitation or exacerbation of neuropathy related to vitaminB12 deficiency. However, as Affect D contains significant B12 this is not a danger. There is some evidence thatdoses of 5 mg per day orally for up to 4 months can be used safely if vitamin B12 levels are routinely measured.Preliminary clinical research suggests daily doses of 800-1200 mcg might increase the risk of cancer and adverse cardiovascular effects if there is impaired liver function. Affect D uses the methyl form of 5-methyltetrahydrofolate and does not relyon liver metabolism. Very high doses of 15 mg per day can cause significant central nervous system (CNS) andgastrointestinal side effects.