120 x 500 mg Capsules Ingredients CNS Factor combination has been researched increase Brain-derived neurotrophic factor (BDNF) levels in the brain. A key ingredient Schisandrin B a well-known adaptogen, cognitive aid,neuroprotective, mood balancing and anti-inflammatory effects.* Ingredients Euphoria longana Houttuynia cordata Dioscorea japonica Schisandra Chinensis (Schisandrin B) (extract 35:1), Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate. Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts. Actions & Indications CNS Factor (NeuroFactor) 120 x 500 mg CapsulesActions Anti-depressantAnxiolyticAdaptogenReduces effects of stressImproves memory, cognition and attentionRegulates heathy sleep cycleIncreases Brain-derived neurotrophic Factors (BDNF)Regulates stress hormone productionReduces serum levels of cortistatin, adrenocorticotropic hormone (ACTH), and corticotropin-releasing factor (CRF)Upregulates GABAA receptorsReduces glutamic acid levelsIncreases serotoninIndications Depression (Treatment-Resistant Depression (TRD))AnxietyChronic stressStress related memory impairmentCognitive impairmentNeurodegenerative conditions Suggested use:3-4 capsules dailyCautions and ContraindicationsCaution in pregnancy.Schisandra may affect medications metabolized by the liver enzymes Cytochrome P450 1A2, 2C9, 3A4, and 3A5 substrates: medications changed by the liver include celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), and warfarin (Coumadin). The doses of the medication might need to be changed.Schisandra may have inhibitory effects on the liver enzyme Cytochrome P450 3A4. Medications metabolized by CYP 450 3A4 include Alprazolam (Xanax), amlodipine (Norvasc), atorvastatin (Lipitor), cyclosporine (Sandimmune), diazepam (Valium), estradiol (Estrace), simvastatin (Zocor), sildenafil (Viagra), verapamil, zolpidem (Ambien)Warfarin (Coumadin) interacts with schisandra: Warfarin (Coumadin) is used to slow blood clotting. The body breaks down warfarin (Coumadin) to get rid of it. Schisandra might increase the breakdown and decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.Anti-epileptic drugs: Benzodiazepines are one of the most common. NeuroFactor is an agonist and will cause drowsiness, and therefore needs to be monitored.May increase effect of Benzodiazepine drugs however, its not contraindicated. Schisandra has been used for Benzodiazepine withdrawal.Supports SSRIs.P-glycoprotein substrates: Lab and human studies suggest schisandra can inhibit Pgp activity and may interfere with the metabolism of certain drugs.Tacrolimus: In liver transplant patients, schisandra increased blood levels of tacrolimus, an immunosuppressant.